​​Sunday September 2, 2018
Session 1:      Welcome and Keynote Speaker


15:30-16:30   Registration: Ilissos Foyer

16:30-16:40   Welcome: Jerry Vockley

16:45-17:45    Keynote:  The Structural Biology of FAO
                                              
Jung-Ja Kim
17:45-18:15    Discussion

19:00-21:30   Networking Reception/Horizon Rooftop Divani Caravel Hotel​​​​


Monday Morning September 3, 2018
Session 2: FAO Outside the Box

7:30-8:30       Registration: Ilissos Foyer / Coffee, Tea, Juices

8:30-9:00       Structural Insights into Drug Therapy of FAODs
                          
Al-Walid Mohsen

9:00-9:30       Tissue Specific Roles of Fatty Acid Oxidation
                          
Michael J. Wolfgang

9:30-9:45      Characterizing the Molecular Architecture
                          of Mitochondrial Energy Metabolism
                          
Yudong Wang

9:45-10:00    Altered Fiber Type Distribution, Reduced Lipid Transport, and Decreased
                          Carnitine Concentrations in Skeletal Muscle of Subjects with Fatty Acid
                          Oxidation Disorders
                         
Oleg Varlamov 

10:00-10:30  Break

Session 3: Cellular Models of FAOD


10:30-11:00  Activation and Alleviation of Cellular Stress Responses in FAO Disorders
                           Martin Lund

11:00-11:30   Cellular Models of  Bioenergetics Defects
​                         
 Guilhian Leipnitz

11:30-11:45   Reduction of Acylcarnitines Restores Electrophysiological Abnormalities
                          in VLCAD Deficient hiPSC-Cardiomyocytes
                          
Suzan J.G. Knottnerus  

11:45-12:00   Restoration of VLCAD in Knockout Mice and Deficient Human
                          Fibroblasts using Novel mRNA Technology: A Model to Treat
                          Fatty Acid β-Oxidation Disorders
                          
Ermal Aliu 


12:00-12:30   Panel Discussion

12:30-14:00   Lunch


Monday Afternoon September 3, 2018

Session 4: New Clinical Insights in FAOD

14:00-14:30   Riboflavin-Responsive Disorders
                          
Manuel Schiff

14:30-15:00  GMDI/SERN VLCAD Nutrition Guidelines
                         
Frances Rohr

15:00-15:15   Novel Therapeutics for Fatty Acid Oxidation Disorders
                         
Paschalis-Thomas Doulias  

15:15 -15:30   Metabolomics Profiling in Dried Blood Spots
                          Differentiates Clinical Phenotypes in VLCADD
                         
Jeannette Bleeker

15:30-15:45   Break


Session 5:    Inflammation and FAOD

15:45-16:15   Inflammation and FAOD in the Pathogenesis of Infection
                         Associated Encephalopathy
                         
Hiroshi Kido

6:15-16:45      The Role of Inflammation in Long Chain FAODs
                            Joel Mroczkowski

16:45-17:00   Mitochondrial H2O2 Generation Via the Acyl-CoA Dehydrogenases
                         
​Eric Goetzman

17:00-17:30   Panel Discussion

17:30-17:35    Summary & Closing remarks

17:00-19:00  Reception & Poster Session

19:15                 INFORM Committee Meeting​​

Learning objectives

After attending the conference, participants will be able to:
Identify disorders of the carnitine cycle and of fatty acid oxidation. Be familiar with biochemical and molecular technology used to confirm the diagnosis of fatty acid oxidation disorders Identify markers that enable pre-symptomatic diagnosis by newborn screening
of fatty acid oxidation disorders Understand controversies in the management of disorders
​of the carnitine cycle and of fatty acid oxidation.

Target audience:
Researchers, pediatricians, internists and specialists in inherited metabolic diseases, nurses, dietitians and nutritionists, genetic counselors, scientists, INFORM members, and all other healthcare professional involved in diagnosing or managing disorders of the carnitine cycle and of fatty acid oxidation. 


The International Network for Fatty Acid Oxidation Research and Management  
was formed in order to promote research and discussion into the cause, diagnosis, and management of inborn errors of fatty acid oxidation. INFORM will sponsor a symposium each year. The Network will provide ​a collaborative framework for ongoing communication and research. Please plan to join us in the future and hear from the experts on a wide range of topics from molecular pathophysiology to treatment strategies. 

INFORM 2018 Agenda
Sunday, September 2nd & Monday, September 3rd preceding the SSIEM in Athens, Greece
Divani Caravel Hotel, Leof. Vasileos Alexandrou 2, Athens 161 21, Greece

INFORM 2018: Carnitine and Fatty Acid Oxidation Disorders

Aim of the Conference:
Disorders of fatty acid oxidation and of the carnitine cycle are an important cause of morbidity and mortality. With the introduction of expanded newborn screening, many of these conditions can be diagnosed and treated at birth, preventing several of the complications. Treatment of these conditions may include fasting-avoidance, diets low in fat containing specific fatty acids, and carnitine supplements. New types of therapies, nutritional and pharmacological, are being tested in humans and animal models of these conditions. Unfortunately, treatment is only partially effective for some conditions and we still do not understand completely the pathophysiology of end-organ damage caused by these inherited disorders.

The objective of the conference is to make the audience familiar with recent advances in the diagnosis and treatment of disorder of fatty acid oxidation and of the carnitine cycle.
The conference will discuss the proper diagnostic interpretation of laboratory testing, development of new therapeutic strategies, and on the role of newborn screening
​in preventing complications. It will also serve as the annual meeting of INFORM.

Children’s Hospital of Pittsburgh/UPMC - Medical Genetics - One Children's Hospital Drive
Faculty Pavilion 1st Floor - 4401 Penn Avenue - Pittsburgh, PA 15224
​Office:  412.692.5099  

 Keith McIntire -  Coordinator, INFORM - keith.mcintire@chp.edu

​​​​​​​INFORM 2018
​September 2nd & 3rd in Athens Greece preceding the SSIEM

Registration is NOW Open ...Click the image above.

Agendas Past and Present

International Network for Fatty Acid Oxidation Research and Management

​INFORM Agendas past/present